24 h area
under the curve (unbound concentration) greater than 100 mg/L*h/MIC (Santimaleeworagun,
Changpradub et al. 2021)
“the MIC median (MIC50), MIC for 90% growth (MIC90), and
range for linezolid were 1.5 µg/mL, 2 µg/mL, and 0.72 - 2 µg/mL, respectively” (Santimaleeworagun,
Changpradub et al. 2021)
The
NextDose default MIC for linezolid is 2 mg/L. The MIC can be changed by adding
MIC observations to patient data.
The occasion
by occasion table of parameters and other variables shows the Bayesian estimate
of clearance (CL L/h), the % difference of the Bayesian clearance from the group
clearance value (fCL%), the Bayesian estimate of volume of distribution (V L), the
% difference of the Bayesian volume from the group volume value (fV%), the
Bayesian estimate of bioavailability (F), the % difference of the Bayesian bioavailability
from the group bioavailability value (fF%), the predicted fat free mass (FFM
kg), the predicted renal function (RF%), the minimum inhibitory concentration
used for the target (MIC) and the Bayesian estimate of the baseline platelet
count (PLT0).
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reserved | Developed by Sam Holford & Nick Holford 2012-2023
Santimaleeworagun, W., D. Changpradub, J. Hemapanpairoa and S. Thunyaharn (2021). "Optimization of linezolid dosing regimens for treatment of vancomycin-resistant enterococci infection." Infection & chemotherapy 53(3): 503.