NextDose: A web-based Bayesian dose forecasting tool

Last updated 29 July 2021

Target Types

Type	NextDose Target Type	Note
Steady state average concentration	Css avg
Steady state concentration at user selected time after dose	Css8h Csstrough	Drug specific time Time of trough concentration determined by user choice of target dosing interval
Area under the curve from 0 to infinity	AUCss 0-inf
Steady state area under the curve over target dosing interval	AUCssDI	Dosing interval (DI) determined by user choice of target dosing interval
Steady state area under the curve over specified interval	AUCss24	AUC over 24 h dosing interval
Steady state average biomarker	INR

Some targets may be scaled by the minimum inhibitory concentration (MIC). In that case the target for scaled concentrations has no units and the target for scaled AUCs has the unit of time (e.g. h).