{"text_format":"1","workbook":"xlsx","n_sheets":2,"sheets":["ka1_turnover","Calc"],"not_rendered":{"charts":1,"images":0,"macros":1,"external_links":0,"defined_names":28,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"ka1_turnover","index":0,"n_rows":29,"n_cols":4,"rows_kept":29,"cut":false,"hidden":false,"merged":[]}
["Parameter","Value","Units","Description"]
[null,"Parameter"]
["CL",9,"L/h","Clearance"]
["V",500,"L","Volume of distribution"]
["ThalfAbs",2,"h","Absorption half-life"]
["Emax",100,"unit","Maximum drug effect"]
["C50",5,"mcg/L","Drug conc at 50% of Emax"]
["R0",10,"unit","Total receptor amount"]
["Kd",10,"mcg/L","Equilibrium binding constant"]
["ThalfOff",5,"h","Binding dissociation half-life"]
[]
[null,"Dosing"]
["Dose",1,"mg","Drug dose at time=0"]
[]
[null,"Calculated"]
["Ke",{"$f":"IF(Kd<=_C50,_C50,_C50*R0/(Kd-_C50))","v":10},"unit","Bound receptor (AR) amount at 50% of Emax "]
[]
[null,"Graph"]
["Tmax",168,"h","Time course maximum"]
[]
[]
[]
[]
[]
[]
[]
[]
["Time course of receptor binding and operational model of agonism; AR=agonist-receptor complex (bound receptor)"]
["Black JW, Leff P. Operational models of pharmacological agonism. Proc R Soc Lond B Biol Sci. 1983;220(1219):141-62."]

{"sheet":"Calc","index":1,"n_rows":202,"n_cols":15,"rows_kept":202,"cut":false,"hidden":false,"merged":[]}
["Time","Gut","Central","AR","Conc","Effect",null,"FuncName","KA1_Binding",null,"Nick Holford","n.holford@auckland.ac.nz",null,null,"2021-03-02"]
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