NextDose: A web-based Bayesian dose forecasting tool

Last updated 17 June 2024

Target Types

Type	NextDose Target Type	Note
Steady state average concentration	Css avg
Steady state concentration at user selected time after dose	e.g. Css2h Csstrough	Drug specific time e.g. target conc 2 h after the dose is given, such as a 1 h infusion with a target conc 1 h after the end of the infusion Time of trough concentration determined by user choice of target dosing interval
Area under the curve from 0 to infinity	AUC0-inf
Steady state area under the curve over target dosing interval	AUCssDI	Dosing interval (DI) determined by user choice of target dosing interval
Steady state area under the curve over specified interval	AUCss24	AUC over 24 h dosing interval
Steady state average biomarker	INR	INR is a biomarker target for warfarin
Cumulative AUC target over indicated duration	e.g. 4 day cum AUC

Some targets may be scaled by the minimum inhibitory concentration (MIC). In that case the target for scaled concentrations has no units and the target for scaled AUCs has the unit of time (e.g. h).