Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland
Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland

NextDose

NextDose: A web-based Bayesian dose forecasting tool

 

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Last updated 15 August 2021


Changes:
Describes updates to NextDose starting with the most recent changes

Background: An introduction to Bayesian forecasting concepts and the development of NextDose

Getting Started: A quick start guide showing how to use NextDose.

Target Concentration: The target concentration principle for rational dose individualization. How to decide on a target. When to observe the drug concentration (or other response).

Target Concentration Intervention: The first dose and next steps of target concentration intervention. How doses are calculated and how to choose a practical dose for administration.

Target Types: A list of types of target available in NextDose

Dose Prediction: The method used for prediction of the dose to achieve the user specified target depends depends on the target. The choices of methods available to the user are described.

Individual Parameters: NextDose uses patient factors (covariates) and observed concentrations (or other responses) to estimate individual pharmacokinetic (and pharmacodynamic) parameters. A description of some key covariate models and interpretation of individual parameters and covariate effects are provided for some of the main medicines available in NextDose

Options: There are a range of options available to reflect patient details and ways of using NextDose including ‘what if’ choices.

Medicines Summary: An overview of the medicines supported by NextDose

Medicines: A description of the individual medicines.

 

 

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