Projects and research

Principal investigator

Research interests include:

Clinical trial simulation

A rational approach to the clinical phases of drug development is based on the application of pharmacokinetic and pharmacodynamic principles. The use of mathematical models to describe and explain human responses to new drugs is being explored using mixed effect nonlinear regression and clinical trial simulation. Current work is exploring methods for the optimal design of clinical trials.

• Holford NHG, Monteleone J, Ko HC, Peck CC. Simulation of clinical trials. Annu Rev Pharmacol Toxicol 2000; 40: 209-234
   

Disease progress and drug action

Clinical pharmacology expresses the combined knowledge of disease and how drugs affect it. Attention is turning towards understanding how drugs affect the long-term progression of disease. Dr Holford is engaged in studies of Parkinson's Disease and Alzheimer's Disease, osteoporosis and depression which describe both the effects of drugs and the natural progression of the disease over time.

• Disease Progression and Drug Action (Advanced Pharmacometrics)

Paediatric dosing

• FirstDose Dosing calculator for Neonates

History of Pharmacometrics

• History of PKPD
  

Tools

• nlmixr